SkinCeuticals A.G.E Interrupter Advanced Anti-Aging Cream - Reduce Wrinkles & Fine Lines - Dermatologist Recommended Skincare for Mature Skin - Perfect for Nighttime Routine & Daily Moisturizing

Advanced Anti-Aging Cream to Visibly Improve Wrinkles, Firmness & Skin Resilience

A.G.E. Interrupter Advanced is SkinCeuticals’ next-generation anti-aging cream, clinically proven to target visible signs of collagen decline and glycation—two key factors responsible for accelerated skin aging. This advanced formula improves the appearance of wrinkles, crepiness, and skin thinning, restoring firmness and elasticity for a visibly more youthful look.

Formulated with a powerful blend of 18% concentrated Proxylane™, wild fruit flavonoids, and glycyrrhetinic acid, it helps reinforce the skin’s barrier, reduce visible signs of aging, and improve skin smoothness and tone over time. Ideal for mature skin experiencing volume loss, dryness, and deep wrinkles.

size: 48ml

SkinCeuticals A.G.E. Interrupter Advanced Product Details

A.G.E. Interrupter Advanced is a potent corrective cream treatment that helps reverse visible signs of aging impacted by collagen decline and glycation, including wrinkles, laxity, and dullness.

This next-generation anti-aging cream is formulated with 18% concentrated Proxylane (+20% more active than previous A.G.E. Interrupter), 4.25% Wild Fruit Flavonoid blend (+12.5% more active), and new ingredients such as 0.1% Glycyrrhetinic Acid. This advanced technology is clinically shown to reduce the look of five types of wrinkles (forehead wrinkles, glabellar line, crow’s feet, nasolabial folds, and marionette lines), restore the skin's firmness & elasticity, and enhance skin's radiance.

What Is Skin Glycation?

Glycation is a natural biological process that contributes to visible skin aging. It occurs when excess sugar molecules attach to collagen and elastin—the proteins responsible for skin’s firmness and elasticity—forming Advanced Glycation End-Products (A.G.E.s). These A.G.E.s weaken the skin’s structural support over time, resulting in common signs of aging.

Common Signs of Glycation-Related Aging

• Fine lines, deep wrinkles, and crepey skin
• Loss of skin firmness and elasticity
• Dull, uneven, or yellow-toned complexion

SkinCeuticals A.G.E. Interrupter Advanced is clinically proven to visibly improve signs of aging related to glycation, including wrinkles, loss of firmness, and crepey skin.

Benefits of SkinCeuticals AGE Interrupter Advanced

• Reduces the appearance of 5 types of wrinkles
• Reduces the appearance of global fine lines by -14.1% and targeted deep wrinkles by -7.9%
• Enhances skin's firmness, elasticity, overall radiance, and improves tone for a healthier-looking complexion
• Delivers rich hydration, with a luxurious, satin finish
• Free of parabens, drying alcohol, and dyes

Clinically Proven Results

After 12 weeks, A.G.E. Interrupter Advanced improved attributes associated with skin aging and glycation, including lines and deep wrinkles in five facial zones.

• 14% Reduction in global fine lines
• 11.5% Reduction in forhead wrinkles
• 11% Reduction in nasolabial folds
• 7% Reduction in marionette wrinkles
• 7% Reduction in glabellar wrinkles
• 7% Reduction in crow's feet lines

Professional Tip from Signature Cosmetic Clinic

We recommend A.G.E. Interrupter Advanced for clients concerned with advanced signs of aging, particularly skin thinning and deep-set wrinkles. It works well as part of a daily anti-aging routine and is especially beneficial for those experiencing age-related volume loss or post-menopausal skin changes. Use morning and night for best results.

For enhanced results, many of our clients also pair this cream with skin tightening treatments like , , or , which help lift and firm the skin from within while A.G.E. Interrupter Advanced supports surface repair and improves visible texture and elasticity.

How To Use A.G.E. Interrupter Advanced

• Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced wrinkle cream onto the entire face, neck, and chest.
• If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

Skin Types:

• Dry
• Combination
• Normal
• Sentitive

Skin Conditions:

• Aging

Key Ingredients

• 18% Concentrated Proxylane
  Helps support the skin’s integrity and correct visible signs of aging, like wrinkles and laxity.
• 4.25% Wild Fruit Flavonoids
  Combination of blueberry and pomegranate extracts helps reduce oxidative stress, which can be linked to A.G.E. formation, and protect against free radical damage.
• 0.1% Glycyrrhetinic Acid
  Helps counter dull tone, which can be linked to A.G.E. accumulation, and is known for its soothing properties.
• 3% Hepes
  Activates natural enzymes in the skin to promote even cell turnover while hydrating the skin.
• 1% Niacinamide
  Water-soluble vitamin, also known as vitamin B3, soothes and helps support the skin’s moisture barrier.